Skip to main content Skip to main navigation menu Skip to site footer
Original article
Austral J. Vet. Sci.
Vol 50, 15-20 (2018)
DOI: 10.4067/S0719-81322018000100104

Energetic metabolic profile of ewes presenting low body condition score induced to subclinical hypocalcemia in early postpartum

1 Universidade Federal de Pelotas (UFPel), Departamento de Clinicas Veterinária, Núcleo de Pesquisa, Ensino e Extensão em Pecuária (NUPEEC), Rio Grande do Sul, Brazil.
2 Universidade Federal de Pelotas (UFPel), Departamento de Clinicas Veterinária, Núcleo de Pesquisa, Ensino e Extensão em Pecuária (NUPEEC), Rio Grande do Sul, Brazil; Universidade Federal do Rio Grande do Sul (UFRGS), Faculdade de Veterinária, Departamento de Medicina Animal, Rio Grande do Sul, Brazil.
Keywords: subclinical hypocalcemia metabolic profile calcemia low body condition sheep

Submitted: 2017-07-31

Accepted: 2017-11-02

Published: 2018-01-01

*Corresponding author:
schmitt.edu@gmail.com

How to Cite

Schmitt, E., Maffi, A. S., Raimondo, R. F. S., Lima, M. E., Hoffmann, D. A. C., Farofa, T. S., Montagner, P., Rincón, J. A. A., Del Pino, F. A. B., & Corrêa, M. N. (2018). Energetic metabolic profile of ewes presenting low body condition score induced to subclinical hypocalcemia in early postpartum. Austral Journal of Veterinary Sciences, 50(1), 15–20. https://doi.org/10.4067/S0719-81322018000100104

License

Copyright (c) 2018 Eduardo Schmitt, Andressa S. Maffi, Raquel F. S. Raimondo, Marcio E. Lima, Dustin A. C. Hoffmann, Tiago S. Farofa, Paula Montagner, Joao A. A. Rincón, Francisco A. B. Del Pino, Marcio N. Corrêa

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

The aim of the present study is to assess plasma concentrations of metabolites related to energy balance in ewes showing low body condition score (BCS) induced to subclinical hypocalcemia in early postpartum. Sixteen crossbred ewes (Ideal x Corriedale) presenting BCS <3 were divided in two groups: 1) control group (n = 9), which received no treatment, and 2) hypocalcemia group (n = 7), which was subjected to twelve hours of induced subclinical hypocalcemia through intravenous Na2EDTA infusion six hours postpartum. Ionized calcium levels were monitored and kept between 0.62 and 0.87 mmol/L. All ewes were subjected to daily blood sampling for five days in order to set the postpartum metabolic profile. There was no interaction between day and treatment in total and ionized calcium concentrations (P>0.05), whereas the mean concentrations of these marks after five days were lower in the hypocalcemia group (P<0.05). However, neither the mean group were different at glucose, non-esterified fatty acids, beta-hydroxybutyrate and insulin (P>0.05) level. These results evidence that, despite the subclinical hypocalcemia induction at early postpartum, ewes presenting low body condition do not change the concentrations of energy balance-related metabolites in the following five days.

Downloads

Download data is not yet available.

References

  1. Aronson AL, Ahrens FA. 1971. The mechanism of renal transport and excretion of ethylenediaminetetraacetate with interspecies comparisons. Toxicol Appl Pharm 18, 1-9.
  2. Balikci E, Yildiz A, Gürdo an F. 2007. Blood metabolite concentrations during pregnancy and postpartum in Akkaraman ewes. Small Ruminant Res 67, 247-251.
  3. Ballou MA, Gomes RC, Juchem O, DePeters EJ. 2009. Effects of dietary supplemental fish oil during the peripartum period on blood metabolites and hepatic fatty acid compositions and total triacylglycerol concentrations of multiparous Holstein cows. J Dairy Sci 92, 657-669.
  4. Bassett JM. 1963. The influence of cortisol on food intake and glucose metabolism in sheep. J Endocrinol 26, 539-553.
  5. Bisello A, Friedman PA. 2008. PTH and PTHrP actions on kidney and bone. In: Bilezikian JP, Raiz LG, Martin TJ (eds). Principles of Bone Biology. Elsevier, San Diego, California, USA, Pp 665-712.
  6. Blum JW, Wilson RB, Kronfeld DS. 1972. Plasma insulin concentrations in parturient cows. J Dairy Sci 56, 459-464.
  7. Braithwaite GD, Glascock RF, Riazuddin S. 1970. Calcium metabolism in pregnant ewes. Br J Nutr 24, 661-670.
  8. Caldeira RM. 2005. Monitorização da adequação do plano alimentar e do estado nutricional em ovelhas. Rev Port Ciênc Vet 100, 125-139.
  9. Cal-Pereyra L, Benech A, González-Montaña JR, Acosta-Dibarrat J, Da Silva S, et al. 2015. Changes in the metabolic profile of pregnant ewes to an acute feed restriction in late gestation. New Zeal Vet J 63, 141-146.
  10. Carvalho PCF, Batello C. 2009. Access to land, livestock production and ecosystem conservation in the Brazilian Campos Biome: the natural grasslands dilemma. Livest Sci 120, 158-162.
  11. Chilliard Y. 1999. Metabolic adaptations and nutrient partitioning in the lactating animal. In: Martinet J, Houdebine LM, Head HH (eds). Biology of Lactation. INRA, Paris, France, Pp 503-552.
  12. Chilliard Y, Ferlay A, Faulconnier Y, Bonnet M, Rouel J, et al. 2000. Adipose tissue metabolism and its role in adaptations to undernutrition in ruminants. Proc Nutr Soc 59, 127-134.
  13. Contreras PA. 2000. Indicadores do mecanismo proteico utilizados nos perfis metabólicos do rebanho. In: Gonzáles FHD, Barcellos JO, Patinõ HO, Ribeiro LA (eds). Perfil metabólico em ruminantes: Seu uso em nutrição e doenças nutricionais. Gráfica UFRGS, Porto Alegre, Brazil, Pp 9-23.
  14. Durak MH, Altiner A. 2006. Effect of energy deficiency during late pregnancy in Chios Ewes on free fatty acids, β-hydroxybutyrate and urea metabolites. Turk J Vet Anim Sci 30, 497-502.
  15. El-khodery S, EL-boshy M, Gaafar K, Elmashad A. 2008. Hypocalcemia in Ossimi sheep associated with feeding on beet tops (Beta vulgaris). Turk J Vet Anim Sci 32, 199-205.
  16. El-sherif MMA, Assad F. 2001. Changes in some blood constituents of Barki ewes during pregnancy and lactation under semi arid conditions. Small Ruminant Res 40, 269-277.
  17. Firat A, Ozpinar A. 2002. Metabolic profile of pre-pregnancy, pregnancy and early lactation in multiple lambing Sakiz ewes 1. Changes in plasma glucose, 3-hydroxybutyrate and cortisol levels. Ann Nutr Metab 46, 57-61.
  18. Fowden AL. 1997.Comparative aspects of fetal carbohydrate metabolism. Equine Vet J 24, 19-25. Goff JP. 2006. Macromineral physiology and application to the feeding of the dairy cow for prevention of milk fever and other periparturient mineral disorders. Anim Feed Sci Tech 126, 237-257.
  19. Harmeyer J, Schlumbohm C. 2006. Pregnancy impairs ketone body disposal in late gestating ewes: implications for onset of pregnancy toxemia. Res Vet Sci 81, 254-264.
  20. Henze P, Bickhardt K, Fuhrmann H. 1994. The contributions of the hormones insulin, cortisol, somatotropin and total estrogen to the pathogenesis of sheep ketosis. Dtsch tierarztl wochenschr 10, 161-165.
  21. Henze P, Bickhardt K, Fuhrmann H, Sallmann HP. 1998. Spontaneous pregnancy toxaemia (ketosis) in sheep and the role of insulin. J Vet Med Series A 45, 255-266.
  22. Herdt TH. 2000. Ruminant adaptation to negative energy balance. Influences on the etiology of ketosis and fatty liver. Vet Clin North Am Food Anim Pract 16, 215-230.
  23. Ingvartsen KL, Andersen JB. 2000. Integration of metabolism and intake regulation: a review focusing on periparturient animals. J Dairy Sci 83, 1573-1597.
  24. Jørgensen RJ. 1999. Induced hypocalcemia by Na2EDTA infusion. A review. J Vet Med 46, 389-407.
  25. Lee SH, Engle TE, Hossner KL. 2002. Effects of dietary copper on the expression of lipogenic genes and metabolic hormones in steers. J Anim Sci 80, 1999-2005.
  26. Loor JJ, Dann HM, Guretzky NAJ. 2006. Plane of nutrition prepartum alters hepatic gene expression and function in dairy cows as assessed by longitudinal transcript and metabolic profiling. Physiol Genomic 27, 29-41.
  27. Mavrogianni VS, Brozos C. 2008. Reflections on the causes and the diagnosis of peri-parturient losses of ewes. Small Ruminant Res 76, 77-82.
  28. Oetzel GR. 2004. Monitoring and testing dairy herds for metabolic disease. Vet Clin North Am 20, 651-674.
  29. Ribeiro LAO, Mattos RC, González FHD, et al. 2004. Perfil metabólico de ovelhas Border Leicester x Texel durante a gestacão e a lactação. Rev Port Ciênc Pet 99, 155-159.
  30. Roubies N, Panousis N, Fytianou A, et al. 2006. Effects of age and reproductive stage on certain serum biochemical parameters of chios sheep under greek rearing conditions. J Vet Med A 53, 277-281.
  31. Russel AJF, Doney JM, Gunn RG. 1969. Subjective assessment of body fat in live sheep. J Agr Sci 72, 451-454.
  32. Rutter GA, Tsuboi T, Ravier MA. 2006. Ca2+ microdomains and the control of insulin secretion. Cell Calcium 40, 539-551.
  33. Schlumbohm C, Harmeyer J. 2003. Hypocalcemia reduces endogenous glucose production in hyperketonemic sheep. J Dairy Sci 86, 1953-1962.
  34. Smith MC, Sherman DM. 1994. Goat Medicine. 1st ed. Lea and Febiger, Philadelphia, USA.
  35. Twardock AR, Symonds HW, Sansom BF, Rowlands GJ. 1973. The effect of litter size upon foetal growth rate and the placental transfer of calcium and phosphorus in superovulated Scottish half-bred ewes. Br J Nutr 29, 437-447.

Make a Submission

Make a Submission

Journal Metrics (2023) & Ranking

Impact Factor
→
0.5 (2024)
5 years Impact Factor
→
0.8
JCR Quartile
→
Q4
JIF Rank
→
134/170 (Veterinary Sciences)
SJR (2024)
→
0.244
SNIP (2024)
→
0.35

 

 

SCImago Journal & Country Rank

Indexed in

Publisher


This journal is published by the Facultad de Ciencias Veterinarias, Universidad Austral de Chile

Keywords