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Austral J. Vet. Sci.
Vol 50, 101-105 (2018)
DOI: 10.4067/S0719-81322018000200101%20

Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations

1 Laboratorio de Inmunología Hospital Veterinario, Unidad Asociada a CONICET-Área de Cs. Agr. Ing. Bio. y S., Universidad Católica de Córdoba, Córdoba, Argentina.
2 E.E.A. Rafaela, INTA, CONICET, Santa Fe, Argentina.
3 Cátedra de Inmunología, Facultad de Medicina, Universidad Católica de Córdoba, Córdoba, Argentina.
4 Establecimiento Los Talas, Potrero de Garay, Córdoba, Argentina.
5 Laboratorio de Inmunología Hospital Veterinario, Unidad Asociada a CONICET-Área de Cs. Agr. Ing. Bio. y S., Universidad Católica de Córdoba, Córdoba, Argentina; Cátedra de Inmunología, Facultad de Medicina, Universidad Católica de Córdoba, Córdoba, Argentina.
Keywords: ISPA adjuvant immunoglobulin G colostrum

Submitted: 2017-08-08

Accepted: 2018-01-24

Published: 2018-05-01

*Corresponding author:
jorauad@gmail.com

How to Cite

Auad, J., Cerutti, J., Cooper, L. G., Camussone, C. M., Lozano, N. A., Crespo, F. M., & Lozano, A. (2018). Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations. Austral Journal of Veterinary Sciences, 50(2), 101–105. https://doi.org/10.4067/S0719-81322018000200101

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Copyright (c) 2018 Jordana Auad, Julieta Cerutti, Laura G. Cooper, Cecilia M. Camussone, Natalia A. Lozano, Francisco M. Crespo, Alejandro Lozano

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Caseous lymphadenitis is a chronic suppurative bacterial disease caused by Corynebacterium pseudotuberculosis, and it has a high prevalence among small ruminants. Different vaccine preparations have been employed to control this disease. The adjuvant used in the formulation is a critical factor for the improvement of vaccine efficacy. No commercial vaccines are available in Argentina. The aims of the present work were to compare the specific antibody response against a C. pseudotuberculosis whole cell vaccine formulated with a classical and an immunoestimulant adjuvant in pregnant goats, and to assess the transfer of vaccine-specific antibodies from the goat to the offspring through colostrum. Twenty three pregnant goats were vaccinated. The animals were randomly allocated to three groups: control, aluminum hydroxide Al(OH)3 adjuvant and a new cage-like particle adjuvant (ISPA). Antibodies (IgG) against this antigen were measured by ELISA. A robust humoral immune response was detected in vaccinated animals, with production of specific IgG. No significant differences were found between the vaccines formulated with different adjuvants. High levels of specific antibodies were detected in colostrum samples from both immunised groups, which were passively transferred from goats to offprings. No adverse local reactions in the vaccines injection sites were detected.

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References

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