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Original article
Austral J. Vet. Sci.
Vol 49, 185-190 (2017)
DOI: 10.4067/S0719-81322017000300185

The effects of Spirulina platensis (Arthrospira platensis) and Saccharomyces cerevisiae on the distribution and cytokine production of CD4+ and CD8+ T-lymphocytes in rabbits

1 Department of Physiology, Faculty of Veterinary Medicine, University of Namik Kemal, Tekirdag, Turkey.
2 Department of Physiology, Faculty of Veterinary Medicine, University of Uludag, Bursa, Turkey.
3 Department of Immunology, Faculty of Medicine, University of Uludag, Bursa, Turkey.
4 Department of Biostatistic, Faculty of Veterinary Medicine, University of Uludag, Bursa, Turkey.
Keywords: rabbits Saccharomyces cerevisiae Spirulina platensis Arthrospira platensis immunity

Submitted: 2017-05-23

Accepted: 2017-07-10

Published: 2017-09-01

*Corresponding author:
nseyidoglu@nku.edu.tr

How to Cite

Seyidoglu, N., Galip, N., Budak, F., & Uzabaci, E. (2017). The effects of Spirulina platensis (Arthrospira platensis) and Saccharomyces cerevisiae on the distribution and cytokine production of CD4+ and CD8+ T-lymphocytes in rabbits. Austral Journal of Veterinary Sciences, 49(3), 185–190. https://doi.org/10.4067/S0719-81322017000300185

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Copyright (c) 2017 Nilay Seyidoglu, Nurten Galip, Ferah Budak, Ender Uzabaci

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Natural additives have become one of the most alternative immune enhancer nowadays. In particular, Spirulina platensis (Arthrospira platensis) (SP) and Saccharomyces cerevisiae (SC) have been used for improving the immune system and quality of life. The aim of this study was to regulate the immune effect of S. cerevisiae and S. platensis (A. platensis) combination. Forty male New Zealand white rabbits, aged 5-6 weeks, were analysed in 4 groups: Control (basal diet); SC (added 3 g/kg diet), SP (added 5% of the diet); SC and SP (added 3 g/kg SC and 5% SP of the diet). The entire experiment lasted 90 days. Blood samples were obtained by ear venipuncture on the 90th day. The CD4+ and CD8+ T lymphocyte values were determined by flow cytometry and cytokines (IFN-γ and IL-4) were determined by ELISA. According to the results, there were no significant differences in the expression of cytokines, but serum CD4+/CD8+ increased in the animals fed SP and SC+SP supplemented diets (3 g/kg and 5% of the diet, respectively). It was concluded that S. platensis (A. platensis) may be used as an immune enhancer, although further studies are needed to clarify the effects of spirulina supplement on immunity.

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