Abstract
Ruminal acidosis in ruminants is a metabolic disorder of gastrointestinal origin that occurs in animals with a high feed intake of cereal grains diets, which affect the performance. According to clinical manifestations it can be classified as: a) acute lactic acidosis with prolonged exposure to ruminal pH ≤ 5.0, triggering a systemic acidosis, with clinical manifestations and changes in biochemical patterns, starting the first twelve hours of ruminal acidosis and it takes 48 to 120 hours to reestablish, b) subacute ruminal acidosis (SARA), it has no clinical manifestations, rumen pH decreases in a range of 5.5 to 5.0 and is held for 111 to 180 minutes in 24 hours, this decrease causes an imbalance in the ruminal metabolism, as well as the fluid balance. Ruminal acidosis can be prevented by adding sodium bicarbonate to the ration, or zootechnic additives such as Saccharomyces cereviseae and Megasphaera elsdenii as well as essential oils (cinnamaldehyde and eugenol). It is also important to consider the forage/concentrate ratio, the forage particle size, the NDF content of the ration, as well as the cereal’s rate of degradation in the rumen. The objective of this review was to address the ruminal acidosis pathophysiology, its effects on animal welfare and control strategies to minimise the detrimental impact on animal production.
Downloads
References
- Anderson VL. 1982. Limestone as a buffer in finishing rations. Farm Research 4, 7-8.
- AARD, Alberta Agriculture and Rural Development. 2000. Nutrition and management of common feed grain. 2nd ed. Alberta, Canada.
- Aschenbach JR, Penner GB, Stumpff F, Gabel G. 2011. Ruminant Nutrition Symposium: Role of fermentation acid absorption in the regulation of ruminal pH. J Anim Sci 89, 1091-1107.
- Askar AR, Guada JA, González JM, de Vega A, Castrillo C. 2011. Effects of sodium bicarbonate on dieta selection and rumen digestion by growing lambs individually fed whole barley grain and protein supplement at their choice. Animal Feed Science and Technology 164, 45-52.
- Bach A, Iglesias D, Devant M. 2007. Daily rumen pH pattern of loosehoused dairy cattle as affected by feeding pattern and live yeast supplementation. Anim Feed Sci Tech 136, 146-153.
- Bevans D, Beauchemin K, Schwartzkof-Genswein K, Mckinnon J, Mcallister T. 2005. Effect of rapid or gradual grain adaptation on subacute acidosis and feed intake by feedlot cattle. J Anim Sci 83, 1116-1132.
- Blanch M, Calsamiglia S, Di-Lorenzo N, Di-Costanzo A, Muetzel S, et al. 2009. Physiological changes in rumen fermentation during acidosis induction and its control using multivalent polyclonal antibody preparation in heifers. J Anim Sci 87, 1722-1730.
- Blanco C, Bodas R, Prieto N, Andrés S, López S, et al. 2014a . Concentrate plus ground barley straw pellets can replace conventional feeding systems for light fattening lambs. Small Ruminant Res 116, 137-143.
- Blanco C, Giráldez F, Prieto N, Benavides J, Wattegedera S, et al. 2014b. Total mixed ration pellets for light fattening lambs: effects on animal health. Animal Consortion, 1-9.
- Bodas R. 2004. El bicarbonato sódico en la alimentación de corderos en la etapa de crecimiento-cebo y de las ovejas en lactación. Tesis PhD, Universidad de León, León, España.
- Bodas R, Giráldez F, Rodríguez A, Mantecón A. 2007. Inclusion of sugar beet pulp in cereal based diets for fattening lambs. Small Ruminant Res 71, 250-254.
- Bolton J, Pass D. 1998. The alimentary tract. In: Robinson WF, Huxtable CRR (ed). Clinic pathologic principles for veterinary medicine. Cambridge University Press, Cambridge, UK, Pp 99-121.
- Boyles S, Anderson V, Koch K. 2015. Feeding barley to cattle beef. Ohio State University Extension, Ohio, USA.
- Brossard L, Martin C, Michalet-Doreau B. 2003. Ruminal fermentative parameters and blood acid-basic balance changes during the onset and recovery of induced latent acidosis in sheep. Anim Res 51, 513-530.
- Brown M, Krebhiel C, Galyean M, Remmenga M, Peters J, et al. 2000. Evaluation of model of acute and subacute acidosis on dry matter intake, ruminal fermentation, blood chemistry, and endocrine profiles of beef steers. J Anim Sci 78, 3155-3169.
- Brown M, Ponce C, Pulikanti R. 2006. Adaptation of beef cattle to high-concentrate diets: Performance and ruminal metabolism. J Anim Sci 84, E25-E33.
- Caja G, González E, Flores C, Carro M, Albanell E. 2003. Alternativas a los antibióticos de uso alimentario en rumiantes: probióticos, enzimas y ácidos orgánicos. FEDNA XIX Curso de especialización, Madrid, España.
- Calsamiglia S, Blanch M, Ferret A, Moya D. 2012. Is subacute acidosis a pH related problem? Causes and tools for its control. Anim Feed Sci Tech 172, 42-50.
- Calsamiglia S, Cardozo P, Ferret A, Bach A. 2008. Changes in rumen microbial fermentation are due to a combined effect of type of diet and pH. J Anim Sci 86, 702-711.
- Cantlapiedra-Hijar G, Yáñez-Ruiz R, Martín-García A, Molina-Alcaide E. 2008. Effects of forage:concentrate ratio and forage type on apparent digestibility, ruminal fermentation, and microbial growth in goats. J Anim Sci 87, 622-631.
- Cardozo P, Calsamiglia S, Ferret A, Kamel C. 2005. Screening for the effects of natural plant extracts at different pH in vitro rumen microbial fermentation of a high concentrate diet for beef cattle. J Anim Sci 83, 2572-2579.
- Cardozo P, Calsamiglia S, Ferret A, Kamel C. 2006. Effects of alfalfa extract, anise, capsicum, and a mixture of cinnamaldehyde and eugenol on ruminal fermentation and protein degradation in beef heifers fed high-concentrate diet. J Anim Sci 88, 2801-2808.
- Carenzi C, Verga M. 2009. Animal welfare: review of the scientific concept and definition. Review Article. Ital J Anim Sci 8, 21-30.
- Castillejos L, Calsamiglia S, Martin-Tereso J, Ter-Wijlen H. 2008. In vitro evaluation of effects of ten essential oils at three doses on ruminal fermentation of high concentrate feedlot-type diets. Anim Feed Sci Tech 155, 259-270.
- Castillo-López E, Wiese B, Hendrick S, Mckinnon J, Mcallister T, et al. 2014. Incidence, prevalence, severity and risk factors for ruminal acidosis in feedlot steers during back grounding diet transition, and finishing. J Anim Sci 92, 3053-3063.
- Céspedes M. 2012. Efecto de la vitamina E en el crecimiento y en la calidad de la canal y de la carne en corderos ligeros. Disertación MSc, Universidad de Zaragoza, Zaragoza, España.
- Clark J, Christensen R, Bateman H, Cummings K. 2009. Effects of sodium sesquicarbonate on dry matter intake and production of milk and milk components by Holstein cows. J Dairy Sci 92, 3354-3363.
- Cobos M, Ley de Coss A, Ramírez N, González S, Ferrera Cerrato R. 2011. Pediococcus acidilactic isolated from the rumen of lambs with rumen acidosis, 166 rRNA identification and sensibility to monensin and lasalocid. Res Vet Sci 90, 26-30.
- Communs L, Mialon MM, Martin C, Baumont R, Veissier I. 2009. Risk of subacute ruminal acidosis in sheep with separate access to forage and concentrate. J Anim Sci 87, 3372-3371.
- Dehghan-Banadaky M, Corbett R, Oba M. 2007. Effects of barley grain processing on productivity of cattle. Anim Feed Sci Tech 137, 1-24.
- Dijkstra J, Ellis J, Kebrab E, Strathe A, Lopez S, et al. 2012. Ruminal pH regulation and nutritional consequences of low pH. Anim Feed Sci Tech 172, 22-23. Erdman R. 1998. Dietary buffering requirements of the lactating cows: a review. J Dairy Sci 71, 3246-3266.
- Fernández D. 2006. Empleo de la pulpa de remolacha en la alimentación del ganado ovino. PhD Dissertation, Universidad de León, León, España.
- Ferreira E, Pires A, Susin I, Mendes C, Queiroz M, et al. 2011. Apparent digestibility, nitrogen balance, and ruminal constituents in ram lambs fed high-concentrate diets containing soybean hulls. J Anim Sci 89, 4127-4133.
- French D. 1973. Chemical and physical properties of starch. J Anim Sci 37, 1048-1064.
- Foskolos A, Siurana A, Rodriguez-Prado M, Ferret A, Bravo D, et al. 2015. The effect of a garlic oil chemical compound, propyl-propane thiosulfate, on ruminal fermentation and fatty acid outflow in a dual-flow continuous culture system. J Dairy Sci 98, 5482-5491.
- Fulton W, Klopfenstein T. 1979. Adaptation to high concentrate diets by beef cattle. II. Effect of ruminal pH alteration on rumen fermentation and voluntary intake of wheat diets. J Anim Sci 48, 785-789.
- Galyean M, Rivera J. 2003. Nutritionally related disorders affecting feedlot cattle. Can J Anim Sci 83, 13-20.
- Garret E, Pereira M, Nordlund K, Armentano L, Goodger W, et al. 1999. Diagnostic methods for the detection of subacute ruminal acidosis in dairy cows. J Dairy Sci 82, 1170-1178.
- Gastaldello A, Pires A, Susin I, Mendes C, Quiroz M, et al. 2013. Limestone with different particle size and sodium bicarbonate to feedlot lambs fed high grain diets with or without monensin. Small Ruminant Res 114, 80-85.
- Giger-Reverdin S, Desnoyers M, Duvaux-Ponter R, Sauvant D. 2006. TI72 Rumen and metabolic acidosis in dairy goats are independent. J Anim Sci 84, 215.
- González L, Manteca X, Calsamiglia S, Schwartzkopf-Genswein K, Ferret A. 2012. Ruminal acidosis in feedlot cattle: Interplay between feed ingredients, rumen function and feeding behavior (a review). Anim Feed Sci Tech 172, 66-79.
- Grant R, Colenbrander V, Mertens D. 1990. Milk fat depression in dairy cows role of silage particle size. J Dairy Sci 73, 1834-1842.
- Hadad S. 2005. Effect of dietary forage:concentrate ratio on growth performance and carcass characteristics of growing Baladi kids. Small Ruminant Res 57, 43-49.
- Haji-Hajikolaei M, Mouri M, Saberi-Afshar F, Jafari-Dekkordi A. 2006. Effects of experimentally induced ruminal lactic acidosis on blood pH, bicarbonate and pCO2 in the sheep. Pakistan Journal of Biological Sciences 9, 2005-2005.
- Hales K, Meniman J, Leibovich J, Vasconcelos J, Quinn M, et al. 2012. Effects of varying bulk densities of steam flaked corn and dietary concentration on in vitro fermentation, performance, carcass quality, and acid-base balance measurements in finishing steers. J Anim Sci 88, 1135-1147.
- Harmon D, Britton R, Prior R, Stock R. 1985. Net portal absorption of lactate and volatile fatty acids in steers experiencing glucose-induced acidosis or fed a 70% concentrate diet ad libitum. J Anim Sci 60, 560-569.
- Hashemi M, Zamani F, Vatankhah M, Hossein-Zadeh S. 2012. Effect of sodium bicarbonate and magnesium oxide on performance and carcass characteristics of Lori-Bakhtiari fattening lambs. Global Veterinaria 8, 89-92.
- Henning P, Horn C, Leeuw K, Meissner H, Hagg F. 2010. Effect of ruminal administration of the lactate utilizing strain Megasphaera elsdenii (Me) NCIMB41125 on abrupt or gradual transition from forage to concentrate diets. Anim Feed Sci Tech 157, 20-29.
- Henning P, Horn C, Stein D, Meissner H, Hagg F. 2010. The potential of Megasphaera elsdenii isolates to control ruminal acidosis. Anim Feed Sci Tech 157, 13-19.
- Hernández J, Benedito J, Abuelo A, Castillo C. 2014. Ruminal acidosis in feedlot: from aetiology to prevention. The Scientific World Journal, ID 702572.
- Herrear-Saldaña R, Huber J, Poore M. 1990. Dry matter, crude protein, and starch degradability of five cereal grains. J Dairy Sci 73, 2386-2393.
- Hewson J. 2003. What is animal welfare? Common definition and their practical consequences. Can Vet J 44, 496-499.
- Hu W, Murphy M. 2005. Statistical evaluation of early and mid lactation dairy cow responses to dietary sodium bicarbonate addition. Anim Feed Sci Tech 119, 43-54.
- Huber T. 1976. Physiological effects of acidosis on feedlot cattle. J Anim Sci 43, 902-909. Huntington G. 1997. Starch utilization by ruminants: from basic to the bunk. J Anim Sci 75, 852-857.
- Iqbal S, Terril S, Zebeli Q, Mazzolari A, Dunn S, et al. 2012. Treating barley grain with lactic acid and heat prevented sub-acute ruminal and increased milk fat in dairy cows. Anim Feed Sci Tech 172, 141-149.
- Kirbas A, Yildirim A, Baydar E, Kandemir M. 2014. Status of lipid peroxidation and some antioxidants in sheep with acute ruminal lactic acidosis. Medycyna Weterynaryjna 70, 357-361.
- Kleen J, Cannizzo C. 2012. Incidence, prevalence and impact of SARA in dairy herds. Anim Feed Sci Tech 4, 4-8.
- Kohn R, Dunlap T. 1998. Calculation of the buffering capacity of bicarbonate in the rumen an in vitro. J Anim Sci 76, 1702-1709.
- Krause K, Oetzel G. 2006. Understanding and preventing subacute ruminal acidosis in dairy herds: A review. Anim Feed Sci Tech 126, 215-236.
- Krause K, Combs D, Beauchemin K. 2002. Effects of forage particle size and grain fermentability in mid lactation cows. II Ruminal pH and chewing activity. J Dairy Sci 85, 1947-1957.
- Laskoski M, Muraro S, Santana-Junior S, Carvalho B, Freitas H, et al. 2014. Sodium bicarbonate as prevention of metabolic acidosis in sheep submitted to experimental ruminal acidosis. Pesqui Vet Brasil 34, 822-826.
- Lean I, Annison F, Bramley E, Browning C, Cusack P, et al. 2007. Ruminal acidosis-understandings, prevention and treatment. A review for veterinarians and nutritional professionals. Australian Veterinary Association 3, 46.
- Lean I, Golder H, Black J, King R, Rabiee A. 2013. In vivo indices for predicting acidosis risk of grain in cattle: Comparison with in vitro methods. J Anim Sci 91, 2823-2835.
- Lettat A, Mozieré P, Silbeerberg M, Morgavi D, Berger C, et al. 2010. Experimental feed induction of ruminal lactic, propionic, o butyric acidosis in sheep. J Anim Sci 88, 3041-3046.
- Li F, Yang X, Cao Y, Li S, Yao J, et al. 2014. Effects of dietary effective fiber to rumen degradable starch rations on the risk of sub-acute ruminal acidosis and rumen content fatty acids compositions in dairy goat. Anim Feed Sci Tech 189, 54-62.
- Liebich H, Derksen G, Arbel E, Dori S, Mayer E. 1987. Fütterungsabhängige Veränderungen der Pansenschleimhaut von Hochleistungskü her im Zeitraum von der trockenstellung bin acht Wochen post partum. J Vet Med 34, 661-672.
- Maulfair D, Mcintyre K, Heinrichs A. 2013. Subacute rumial acidosis and total mixed ration preference in lactating dairy cows. J Dairy Sci 96, 6610-6620.
- Meschy F, Bravo D, Sauvant D. 2004. Analyse quantitative des response des vaches laitieres á l’apport de substances tampon. Prod Anim 17, 11-18.
- Minuti A, Ahmed S, Trevisi E, Piccioli-Capelli F, Bertoni G, et al. 2014. Experimental acute acidosis in sheep. Consequences on clinical, rumen, and gastrointestinal permeability conditions and blood chemistry. J Anim Sci 92, 3966-3077.
- Morán L, Giráldez F, Bodas R, Benavides J, Prieto N, et al. 2013. Metabolic acidosis corrected by including antioxidants in the diet of fatting lambs. Small Rumin Res 109, 133-135.
- Morán L, Andrés S, Bodas R, Benavides J, Prieto N, et al. 2012. Antioxidants included in the diet of fattening lambs: Effects on inmune response, stress, welfare and distal gut microbiota. Anim Feed Sci Tech 173, 177-175.
- Nikkah A. 2012. Barley grain for ruminants: A global treasure or tragedy. J Anim Sci Biotechno 3, 1-22. Nocek J. 1997. Bovine acidosis: implications on laminitis. J Dairy Sci 80, 1005-1028. NRC, National Research Council. 2001. The nutrient requirements of dairy cattle. 7th ed. National Academies Press, Washington, DC, USA.
- Oba M, Wertz-Lutz A. 2011. Ruminant nutrition symposium: Acidosis, new insights into the persistent problem. J Anim Sci 89, 1090-1091.
- Odongo N, Alzahal O, Lindenger M, Duffield T, Valdes E, et al. 2006a . Effects of mild heat stress and grain challenge on acid-base balance and rumen tissue histology in lambs. J Anim Sci 84, 447-455.
- Odongo N, Las J, Wadud S, Aizahal O, Lindinger M, et al. 2006b. T173 Effects of chronic metabolic acidosis on acid-base balance and plasma free amino acids in lambs. J Anim Sci 84, 215.
- Patra R, Lal S, Swarup D. 1991. Physicochemical alterations in blood cerebrospinal fluid and urine in experimental lactic acidosis in sheep. Res Vet Sci 54, 217-22.
- Penner G, Aschenbach J, Gäbel G, Oba M. 2009. Technical note: Evaluation of a continuous pH measurement system for use in noncanulated small ruminants. J Anim Sci 87, 2363-2366.
- Penner G, Oba M, Gäbel G, Aschenbach J. 2010. A single mild episode of subacute ruminal acidosis does not affect ruminal barrier function in short term. J Dairy Sci 93, 4838-4845.
- Penner G, Steel M, Aschenbach J, Mcbride B. 2011. Ruminant Nutrition Symposium: Molecular adaptation on ruminal epithelia to highly fermentable diets. J Anim Sci 89, 1108-1119.
- Plaizer J, Khafipours E, Li S, Gozho G, Krause D. 2012. Subacute ruminal acidosis (SARA) endotoxin and health consequences. Anim Feed Sci Tech 171, 9-21.
- Pugh D. 2002. Sheep and Goat Medicine. 1st ed. Saunders, Philadelphia, USA.
- Rauch R, Robinson P, Erasmus L. 2012. Effects of sodium bicarbonate and calcium magnesium carbonate supplementation on performance of high producing dairy cows. Anim Feed Sci Tech 177, 180-193.
- Rustom B, Aizahal O, Cant J, Fan M, Duffield T, et al. 2006. T175 Effects of rumen acid-load from feeds on ruminal pH, dry matter intake, fiber degradability and milk production in the lactating dairy cow. J Anim Sci 84, 216.
- Sauvant D, Mertens D. 2001. Empirical modeling of ruminal pH from dietary NDF and mean particle size. J Anim Sci 79, 198-199, Suppl. 1, 105.
- Sayago A, Marín M, Aparicio R, Morales M. 2007. Vitamina E y aceites vegetales. Grasas y Aceites 58, 74-79.
- Schwaiger T, Bauchemin K, Penner G. 2013. The duration of time that cattle are fed a high-grain diet affects the recovery from a bout of ruminal acidosis. Dry matter intake and ruminal fermentation. J Anim Sci 91, 5729-5742.
- Sendi J, Drouillerd J, Montgomery S, Loe E. 2006. Factors influencing characteristics of steam flaked and utilization by finishing cattle. J Anim Sci 84, 154-161.
- Shu Q, Gill H, Leng R, Browe J. 2000. Inmunization with Streptococcus bovis vaccine administred by different routes against lactic acidosis in sheep. Vet J 159, 262-269.
- Smith R. 1998. Impact of diseases on feedlot performance: A review. J Anim Sci 76, 272-274.
- Steel M, Alzahal O, Hook D, Croom J, McBride B. 2009. Ruminal acidosis and the rapid onset of ruminal parakeratosis in a mature dairy cow: a case report. Acta Vet Scand 51, 39.
- Sudweeks E, Ely O, Mertens D, Sisk L. 1981. Assessing minimum amount and form of roughage in ruminant diets: roughage value index system. J Anim Sci 53, 1406-1411.
- Svikus B, Uhlem A, Hastad O. 2005. Effect of starch granule structure, associated components and processing nutritive value of cereal starch: A review. Anim Feed Sci Tech 122, 303-320.
- Theurer C, Lozano O, Aliv A, Delgado-Elorduy A, Sadik M, et al. 1999. Steam processed corn and sorghum grain flaked at different densities alter ruminal, small intestinal and total tract digestibility of starch by steers. J Anim Sci 77, 2824-2831.
- Tománková O, Homlka P. 2004. In vitro ruminal degradation of cereal grain starch. Czech Journal of Animal Science 49, 151-155.
- Uyeno Y, Akiyama K, Hasunuma T, Yamamoto H, Yokokawa H, et al. 2017. Effects of supplementing an active dry yeast product on rumen microbial community composition and on subsequent rumen fermentation of lacting cows in the mid-to-late lactation period. Anim Sci J 88, 119-124.
- Van Vuuren AD, Calsamiglia S, Udén P. 2012. Rumen health: A 360º analysis. Anim Feed Sci Tech 172, 1-3.
- Vyas D, Uwsvizeye A, Mohammed R, Yang WZ, Walker ND, et al. 2014a . The effects of active dried, killed dried yeast on subacute ruminal acidosis, ruminal fermentation and nutrient digestibility in beef heifers. J Anim Sci 92, 724-732.
- Vyas D, Uwsvizeye A, Yang WZ, Beauchemin KA. 2014b. Importance of yeast viability for reducing the effects of ruminal acidosis in beef heifers during and following an imposed acidosis challenge. Anim Feed Sci Tech 197, 103-113.
- Waldo DR. 1973. Extent and partition of cereal grain starch digestion in ruminants. J Anim Sci 37, 1062-1074.
- Wenping H, Kung JL, Murphy MR. 2007. Relationship between dry matter intake and acid-base status of lacting dairy cows as manipulated by dietary cation-anion difference. Anim Feed Sci Tech 136, 216-225.
- Yang Z, Beauchemin KA. 2006. T177 Effect of physically effective fiber on chewing and ruminal pH of dairy cows fed diets containing barley or corn grain. J Anim Sci 84, Suppl. 1, 215.
- Zebeli Q, Aschenbach JR, Tafaj M, Boguhn J, Ametaj BN, et al. 2012. Role of physically effective fiber and estimation of dietary fiber adequacy in high-producing dairy cattle. J Dairy Sci 95, 1041-1056.
- Zhao X, Zhang T, Xu M, Yao J. 2011. Effects of physically effective fiber on chewing activity, ruminal fermentation, and digestibility in goats. J Dairy Sci 89, 501-509.




