Abstract
A group of horses died in Easter Island following anorexia, weight loss and neurological signs. Similar cases have occurred since the introduction of a plant containing pirrolizidine alkaloid to the island. This study describes the grazing behaviour of the horses and the potential correlation with the development of these horses clinical signs.
Downloads
Download data is not yet available.
References
- Albrecht J, Norenberg MD. 2006. Glutamine: a Trojan horse in ammonia neurotoxicity. Hepatology 44, 788-794. Artz J, Mount M. 1999. Hepatotoxity associated with pyrrolizidine alkaloid (Crotalaria spp.) Ingestion in a horse on Easter Island. Vet Hum Toxicol 41, 96-99.
- Börgel L, Lohse J, Ayerdi MT, Valenzuela L, Sunko D. 2013. Identification and determination of pyrrolizidine alkaloids: crotaline, heliotrine and retrorsine by infrared spectroscopy method in biological equine and environmental samples in Easter Island. Proceedings of XIII International Congress of Toxicology, Seoul, South Korea, Pp 2-66.
- Botha CJ, Lewis A, Du Plessis EC, Clift SJ, Williams M. 2012. Crotalariosis equorum (“jaagsiekte”) in horses in southern Mozambique, a rare form of pyrrolizidine alkaloid poisoning. J Vet Diagn Invest 24, 1099-1104.
- Dubois A, Lenne P, Nahoe E, Rauch M. 2013. Plantas de Rapa Nui. Guía Ilustrada de la Flora de Interés Ecológico y Patrimonial. Umanga Mo Te Natura, CONAF y ONF International, Santiago. Chile.
- Etienne M, Michel GE, Díaz E. 1982. Flora, vegetación y potencial pastoral de Isla de Pascua. Boletín Técnico 47, Facultad de Ciencias Agrarias, Veterinarias y Forestales, Universidad de Chile, Santiago, Chile.
- Fu PP, Xia Q, Lin G, Chou MW. 2002. Genotoxic pyrrolizidine alkaloids - mechanisms leading to DNA adduct formation and tumorigenicity. Int J Mol Sci 3, 948-964.
- Fuentes F. 1913. Reseña botánica sobre la Isla de Pascua. Boletín Museo Nacional de Historia Natural 5, 320-327.
- Lecocq C, Moreira R. 2006. Reporte de un caso cuadro neurológico en equinos, Isla de Pascua, Chile. Salud Animal e Inocuidad de los Alimentos. División de Protección Pecuaria, Boletín Veterinario Oficial del SAG 7, 2-6.
- Montoya MJ. 2011. Diagnóstico técnico y social de las prácticas ganaderas en Isla de Pascua. MOBA Consultora ambiental, Santiago, Chile.
- Santos JC, Riet-Correa F, Simoes S, Barros C. 2008. Patogênese, sinais clínicos e patologia das doenças causadas por plantas hepatotóxicas em ruminantes e eqüinos no Brasil. Pesq Vet Bras 28, 1-14.
- Stegelmeier BL, Edgar JA, Colegate SM, Gardner DR, Schoch TK, et al. 1999. Pyrrolizidine alkaloid plants, metabolism and toxicity. J Nat Toxins 8, 95-116.
- Stegelmeier B. 2011. Pyrrolizidine Alkaloid-containing toxic plants (Senecio, Crotalaria, Cynoglossum, Amsinckia, Heliotropium, and Echium spp.). Vet Clin North Am Food Anim Pract 27, 419-428.
- Stegelmeier B, Colegate SM, Brown AW. 2016. Dehydropyrrolizidine alkaloid toxicity, cytotoxicity, and carcinogenicity. Toxins (Basel) 8, 356.
- Yan X, Kang H, Feng J, Yang Y, Tang K, et al. 2016. Identification of toxic pyrrolizidine alkaloids and their common hepatotoxicity mechanism. Int J Mol Sci 17, 318. Yang X, Wang H, Ni HM, Xiong A, Wang Z, et al. 2017. Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice. Redox Biol 12, 264-273.




