Abstract
This study aimed to compare the clinical and paraclinical effects of inhalational isoflurane anesthesia with intraosseous propofol anesthesia in rabbits. Twelve healthy white rabbits (2 kg, 12 months old) were randomly allocated to two groups (n = 6). Group 1 received intraosseous propofol, and Group 2 underwent induction and maintenance with isoflurane for 30 min. Heart rate, respiratory rate, rectal temperature, and oxygen saturation were recorded every 5 min during anesthesia. Hematological and serum biochemical parameters were evaluated pre-and post-anesthesia. Hematological parameters and biochemical indices were measured in each group pre- and post-anesthesia, and changes in these variables were compared between the two groups. Heart rate remained comparable between the groups, except at 5, 10, and 25 min post-induction. The respiratory rate differed significantly between the groups throughout the duration of anesthesia in both groups (P < 0.05). Hematocrit, hemoglobin, and red and white blood cell counts decreased post-anesthesia, with greater reductions in hematocrit and hemoglobin in the isoflurane group (P < 0.05). Serum activities of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT) significantly declined in both groups (P < 0.05). Intraosseous propofol provided rapid induction, stable cardiopulmonary parameters, and acceptable biochemical safety, whereas isoflurane offered superior oxygenation. These findings suggest that intraosseous propofol administration is a practical alternative when venous catheterization or airway intubation is difficult, especially in emergency situations.
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